Irene Mayer Selznick (April 2, 1907 - October 10, 1990) was an American theatrical producer.
Born Irene Gladys Mayer in Brooklyn, New York, she was the daughter of future MGM studio mogul, Louis B. Mayer and his first wife, Margaret Shenberg. She was an adventurous young girl of considerable intellect who became a lifelong friend of actress Katharine Hepburn. Irene Mayer married David O. Selznick on April 29, 1930. They had two sons, Jeffrey and Daniel Selznick. Her husband came from an extremely dysfunctional but talented family and he was one of the few men who could stimulate her intellect. However, his constant philandering and frequent financial problems as a result of a gambling addiction led to their growing apart and she eventually left Selznick. Their divorce was finalized in January 1949.